Ontology highlight
ABSTRACT:
SUBMITTER: Khan OF
PROVIDER: S-EPMC4825876 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Nano letters 20150402 5
Targeted RNA delivery to lung endothelial cells has the potential to treat conditions that involve inflammation, such as chronic asthma and obstructive pulmonary disease. To this end, chemically modified dendrimer nanomaterials were synthesized and optimized for targeted small interfering RNA (siRNA) delivery to lung vasculature. Using a combinatorial approach, the free amines on multigenerational poly(amido amine) and poly(propylenimine) dendrimers were substituted with alkyl chains of increasi ...[more]