Revealing the Micro-scale Signature of Endemic Zoonotic Disease Transmission in an African Urban Setting.

ABSTRACT: The development of novel approaches that combine epidemiological and genomic data provides new opportunities to reveal the spatiotemporal dynamics of infectious diseases and determine the processes responsible for their spread and maintenance. Taking advantage of detailed epidemiological time series and viral sequence data from more than 20 years reported by the National Reference Centre for Rabies of Bangui, the capital city of Central African Republic, we used a combination of mathematical modeling and phylogenetic analysis to determine the spatiotemporal dynamics of rabies in domestic dogs as well as the frequency of extinction and introduction events in an African city. We show that although dog rabies virus (RABV) appears to be endemic in Bangui, its epidemiology is in fact shaped by

SUBMITTER: Bourhy H 

PROVIDER: S-EPMC4825935 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature