Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection.

ABSTRACT:

Background

Nontyphoidal strains of Salmonella are a leading cause of death among HIV-infected Africans. Antibody-induced complement-mediated killing protects healthy Africans against Salmonella, but increased levels of anti-lipopolysaccharide (LPS) antibodies in some HIV-infected African adults block this killing. The objective was to understand how these high levels of anti-LPS antibodies interfere with the killing of Salmonella.

Methodology/principal findings

Sera and affinity-purified antibodies from African HIV-infected adults that failed to kill invasive S. Typhimurium D23580 were compared to sera from HIV-uninfected and HIV-infected subjects with bactericidal activity. The failure of sera from certain HIV-infected subjects to kill Salmonella was found to be due to an i

SUBMITTER: Goh YS 

PROVIDER: S-EPMC4825999 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature