Comprehensive Transcriptome Meta-analysis to Characterize Host Immune Responses in Helminth Infections.

ABSTRACT: Helminth infections affect more than a third of the world's population. Despite very broad phylogenetic differences among helminth parasite species, a systemic Th2 host immune response is typically associated with long-term helminth infections, also known as the "helminth effect". Many investigations have been carried out to study host gene expression profiles during helminth infections. The objective of this study is to determine if there is a common transcriptomic signature characteristic of the helminth effect across multiple helminth species and tissue types. To this end, we performed a comprehensive meta-analysis of publicly available gene expression datasets. After data processing and adjusting for study-specific effects, we identified ~700 differentially expressed genes that are cha

SUBMITTER: Zhou G 

PROVIDER: S-EPMC4826001 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature