Association between serum fatty acids and lipoprotein subclass profile in healthy young adults: exploring common genetic and environmental factors.

ABSTRACT:

Objective

Little is known about the associations of serum fatty acids with lipoprotein profile and the underlying genetic and environmental etiology of these relationships. We aimed to analyze the phenotypic association of serum n-6 and n-3 polyunsaturated (PUFAs), monounsaturated (MUFAs) and saturated (SFAs) fatty acids (relative proportion to total fatty acids) with lipids and lipoproteins, and to quantify common genetic and environmental factors determining their covariation.

Methods

Two cohorts of healthy Finnish twins were assessed in young adulthood. Data were available for 1269 individual twins including 561 complete pairs. Serum metabolites were measured by nuclear magnetic resonance spectroscopy. Bivariate quantitative genetic models were used to decompose the pheno

SUBMITTER: Jelenkovic A 

PROVIDER: S-EPMC4826157 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature