Liver irradiation causes distal bystander effects in the rat brain and affects animal behaviour.

ABSTRACT: Radiation therapy can not only produce effects on targeted organs, but can also influence shielded bystander organs, such as the brain in targeted liver irradiation. The brain is sensitive to radiation exposure, and irradiation causes significant neuro-cognitive deficits, including deficits in attention, concentration, memory, and executive and visuospatial functions. The mechanisms of their occurrence are not understood, although they may be related to the bystander effects.We analyzed the induction, mechanisms, and behavioural repercussions of bystander effects in the brain upon liver irradiation in a well-established rat model.Here, we show for the first time that bystander effects occur in the prefrontal cortex and hippocampus regions upon liver irradiation, where they manifest as alte

SUBMITTER: Kovalchuk A 

PROVIDER: S-EPMC4826213 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature