P130Cas scaffold protein regulates ErbB2 stability by altering breast cancer cell sensitivity to autophagy.

ABSTRACT: Overexpression of the ErbB2/HER2 receptor tyrosine kinase occurs in up to 20% of human breast cancers and correlates with aggressive disease. Several efficacious targeted therapies, including antibodies and kinase inhibitors, have been developed but the occurring of resistance to these agents is often observed. New therapeutic agents targeting the endocytic recycling and intracellular trafficking of membrane in tumor cells overexpressing ErbB2 are actually in clinical development. Nevertheless the mechanisms underlying ErbB2 downregulation are still obscure. We have previously demonstrated that the overexpression of the p130Cas adaptor protein in ErbB2 positive breast cancer, promotes tumor aggressiveness and progression. Here we demonstrate that lowering p130Cas expression in breast cance

SUBMITTER: Bisaro B 

PROVIDER: S-EPMC4826217 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature