Synthetic analogues of the active site of the A-cluster of acetyl coenzyme A synthase/CO dehydrogenase: syntheses, structures, and reactions with CO.

ABSTRACT: Two metallosynthons, namely (Et4N)2[Ni(NpPepS)] (1) and (Et4N)2[Ni(PhPepS)] (2) containing carboxamido-N and thiolato-S as donors have been used to model the bimetallic M(p)-Ni(d) subsite of the A-cluster of the enzyme acetyl coenzyme A synthase/CO dehydrogenase. A series of sulfur-bridged Ni/Cu dinuclear and trinuclear complexes (3-10) have been synthesized to explore their redox properties and affinity of the metal centers toward CO. The structures of (Et4N)2[Ni(PhPepS)] (2), (Et4N)[Cu(neo)Ni(NpPepS)] x 0.5 Et2O x 0.5 H2O (3 x 0.5 Et2O x 0.5 H2O), (Et4N)[Cu(neo)Ni(PhPepS)] x H2O (4 x H2O), (Et4N)2[Ni{Ni(NpPepS)}2] x DMF (5 x DMF), (Et4N)2[Ni(DMF)2{Ni(NpPepS)}2] x 3 DMF (6 x 3 DMF), (Et4N)2[Ni(DMF)2{Ni(PhPepS)}2] (8), and [Ni(dppe)Ni(PhPepS)] x CH2Cl2 (10 x CH2Cl2) have been determined by

SUBMITTER: Harrop TC 

PROVIDER: S-EPMC4826277 | biostudies-literature | 2006 Apr

REPOSITORIES: biostudies-literature