Dataset Information

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.

ABSTRACT:

Background

Psychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging.

Methods

Data were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, the ratio of late-differentiated effector (CCR7-CD45RA+CD27-CD28-) to naïve (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells.

Results

In models adjusted for age, gender, race/ethnicity, education, smoking status, and medication use, we found that past-year PTSD was associated with statistically significant differences in the CD8+ T cell population, including a higher ratio of late-differentiated effector to naïve T cells, a higher percentage of KLRG1+ cells, and a higher percentage of CD57+ cells. The percentage of CD57+ cells in the CD4 subset was also significantly higher and the CD4:CD8 ratio significantly lower among individuals who had experienced past-year PTSD. Lifetime PTSD was also associated with differences in several parameters of immune aging.

Conclusions

PTSD is associated with an aged immune phenotype and should be evaluated as a potential catalyzer of accelerated immunological aging in future studies.

SUBMITTER: Aiello AE

PROVIDER: S-EPMC4826331 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature

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Publications

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.

Aiello Allison E AE Dowd Jennifer B JB Jayabalasingham Bamini B Feinstein Lydia L Uddin Monica M Simanek Amanda M AM Cheng Caroline K CK Galea Sandro S Wildman Derek E DE Koenen Karestan K Pawelec Graham G

Psychoneuroendocrinology 20160203

<h4>Background</h4>Psychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging.<h4>Methods</h4>Data were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, ...[more]

PMID: 26894484

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Dataset Information

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.

Background

Methods

Results

Conclusions

Publications

PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.

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