PTSD is associated with an increase in aged T cell phenotypes in adults living in Detroit.

ABSTRACT:

Background

Psychosocial stress is thought to play a key role in the acceleration of immunological aging. This study investigated the relationship between lifetime and past-year history of post-traumatic stress disorder (PTSD) and the distribution of T cell phenotypes thought to be characteristic of immunological aging.

Methods

Data were from 85 individuals who participated in the community-based Detroit Neighborhood Health Study. Immune markers assessed included the CD4:CD8 ratio, the ratio of late-differentiated effector (CCR7-CD45RA+CD27-CD28-) to naïve (CCR7+CD45RA+CD27+CD28+) T cells, the percentage of KLRG1-expressing cells, and the percentage of CD57-expressing cells.

Results

In models adjusted for age, gender, race/ethnicity, education, smoking status, and medi

SUBMITTER: Aiello AE 

PROVIDER: S-EPMC4826331 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature