Association of REL polymorphisms and outcome of patients with septic shock.

ABSTRACT:

Background

cRel, a subunit of NF-κB, is implicated in the inflammatory response observed in autoimmune disease. Hence, knocked-out mice for cRel had a significantly higher mortality, providing new and important functions of cRel in the physiopathology of septic shock. Whether genetic variants in the human REL gene are associated with severity of septic shock is unknown.

Methods

We genotyped a population of 1040 ICU patients with septic shock and 855 ICU controls for two known polymorphisms of REL; REL rs842647 and REL rs13031237. Outcome of patients according to the presence of REL variant alleles was compared.

Results

The distribution of REL variant alleles was not significantly different between patients and controls. Among the septic shock group, REL rs13031237*T m

SUBMITTER: Toubiana J 

PROVIDER: S-EPMC4826362 | biostudies-literature | 2016 Dec

REPOSITORIES: biostudies-literature