Neural Correlates of Decision Thresholds in the Human Subthalamic Nucleus.

ABSTRACT: If humans are faced with difficult choices when making decisions, the ability to slow down responses becomes critical in order to avoid suboptimal choices. Current models of decision making assume that the subthalamic nucleus (STN) mediates this function by elevating decision thresholds, thereby requiring more evidence to be accumulated before responding [1-9]. However, direct electrophysiological evidence for the exact role of STN during adjustment of decision thresholds is lacking. Here, we show that trial-by-trial variations in STN low-frequency oscillatory activity predict adjustments of decision thresholds before subjects make a response. The relationship between STN activity and decision thresholds critically depends on the subjects' level of cautiousness. While increased oscillatory

SUBMITTER: Herz DM 

PROVIDER: S-EPMC4826434 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature