Protective Effect of Contemporary Pertussis Vaccines: A Systematic Review and Meta-analysis.

ABSTRACT:

Background

Acellular pertussis (aP) and whole-cell (wP) pertussis vaccines are presumed to have similar short-term (<3 years after completion of the primary series) efficacy. However, vaccine effect varies between individual pertussis vaccine formulations, and many originally studied formulations are now unavailable. An updated analysis of the short-term protective effect of pertussis vaccines limited to formulations currently on the market in developed countries is needed.

Methods

We conducted a systematic review and meta-analysis of published studies that evaluated pertussis vaccine efficacy or effectiveness within 3 years after completion (>3 doses) of a primary series of a currently available aP or wP vaccine formulation. The primary outcome was based on the World Health

SUBMITTER: Fulton TR 

PROVIDER: S-EPMC4826451 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature