Ontology highlight
ABSTRACT:
SUBMITTER: Puram RV
PROVIDER: S-EPMC4826477 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Cell 20160401 2
Leukemia stem cells (LSCs) have the capacity to self-renew and propagate disease upon serial transplantation in animal models, and elimination of this cell population is required for curative therapies. Here, we describe a series of pooled, in vivo RNAi screens to identify essential transcription factors (TFs) in a murine model of acute myeloid leukemia (AML) with genetically and phenotypically defined LSCs. These screens reveal the heterodimeric, circadian rhythm TFs Clock and Bmal1 as genes re ...[more]