Biodistribution and fate of core-labeled ¹²⁵I polymeric nanocarriers prepared by Flash NanoPrecipitation (FNP).

ABSTRACT: Non-invasive medical imaging techniques such as positron emission tomography (PET) imaging are powerful platforms to track the fate of radiolabeled materials for diagnostic or drug delivery applications. Polymer-based nanocarriers tagged with non-standard PET radionuclides with relatively long half-lives (e.g. ⁶⁴Cu: t_1/2 = 12.7 h, ⁷⁶Br: t_1/2 = 16.2h, ⁸⁹Zr: t_1/2 = 3.3 d, ¹²⁴I: t_1/2 = 4.2 d) may greatly expand applications of nanomedicines in molecular imaging and therapy. However, radiolabeling strategies that ensure stable in vivo association of the radiolabel with the nanocarrier remain a significant challenge. In this study, we covalently attach radioiodine to the core of pre-fabricated nanocar

SUBMITTER: Tang C 

PROVIDER: S-EPMC4826598 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature