Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Objective

Various definitions of metabolic health have been proposed to explain differences in the risk of type 2 diabetes within BMI categories. The goal of this study was to assess their predictive relevance.

Research design and methods

We performed systematic searches of MEDLINE records for prospective cohort studies of type 2 diabetes risk in categories of BMI and metabolic health. In a two-stage meta-analysis, relative risks (RRs) specific to each BMI category were derived by network meta-analysis and the resulting RRs of each study were pooled using random-effects models. Hierarchical summary receiver operating characteristic curves were used to assess predictive performance.

Results

In a meta-analysis of 140,845 participants and 5,963 incident cases of type 2 d

SUBMITTER: Lotta LA 

PROVIDER: S-EPMC4826609 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature