Prognostic Relevance of Left Atrial Dysfunction in Heart Failure With Preserved Ejection Fraction.

ABSTRACT:

Background

Left atrial (LA) size is an established marker of risk for adverse outcomes in heart failure with preserved ejection fraction (HFpEF). However, the independent prognostic importance of LA function in HFpEF is not known.

Methods and results

We assessed LA function measured by speckle-tracking echocardiography in 357 patients with HFpEF enrolled in the Treatment Of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist (TOPCAT) trial who were in sinus rhythm at the time of echocardiography. Lower peak LA strain, indicating LA dysfunction, was associated with older age, higher prevalence of atrial fibrillation and left ventricular (LV) hypertrophy, worse LV and right ventricular systolic function, and worse LV diastolic function. At a mean follow-up

SUBMITTER: Santos AB 

PROVIDER: S-EPMC4826720 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature