Protein tyrosine kinase 7 is essential for tubular morphogenesis of the Wolffian duct.

ABSTRACT: The Wolffian duct, the proximal end of the mesonephric duct, undergoes non-branching morphogenesis to achieve an optimal length and size for sperm maturation. It is important to examine the mechanisms by which the developing mouse Wolffian duct elongates and coils for without proper morphogenesis, male infertility will result. Here we show that highly proliferative epithelial cells divide in a random orientation relative to the elongation axis in the developing Wolffian duct. Convergent extension (CE)-like of cell rearrangements is required for elongating the duct while maintaining a relatively unchanged duct diameter. The Wolffian duct epithelium is planar polarized, which is characterized by oriented cell elongation, oriented cell rearrangements, and polarized activity of regulatory ligh

SUBMITTER: Xu B 

PROVIDER: S-EPMC4826835 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature