Robust estimation of the proportion of treatment effect explained by surrogate marker information.

ABSTRACT: In randomized treatment studies where the primary outcome requires long follow-up of patients and/or expensive or invasive obtainment procedures, the availability of a surrogate marker that could be used to estimate the treatment effect and could potentially be observed earlier than the primary outcome would allow researchers to make conclusions regarding the treatment effect with less required follow-up time and resources. The Prentice criterion for a valid surrogate marker requires that a test for treatment effect on the surrogate marker also be a valid test for treatment effect on the primary outcome of interest. Based on this criterion, methods have been developed to define and estimate the proportion of treatment effect on the primary outcome that is explained by the treatment effect

SUBMITTER: Parast L 

PROVIDER: S-EPMC4826843 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature