Long-term treatment with egg oral immunotherapy enhances sustained unresponsiveness that persists after cessation of therapy.

ABSTRACT:

Background

We previously reported the results of a randomized placebo-controlled study of egg oral immunotherapy (eOIT) in which 27.5% of subjects achieved sustained unresponsiveness (SU) after 2 years. Here we report the results of treatment through 4 years and long-term follow-up.

Objective

We sought to evaluate the efficacy and safety of eOIT in participants treated up to 4 years.

Methods

Children with egg allergy (5-18 years old) received eOIT (n = 40) for up to 4 years or placebo (n = 15) for 1 year or less. The key outcome was the percentage of subjects achieving SU by year 4. Safety and immunologic assessments were performed, and long-term follow-up questionnaires (LFQs) were administered after study conclusion (LFQ-1) and 1 year later (LFQ-2).

Results

O

SUBMITTER: Jones SM 

PROVIDER: S-EPMC4826859 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature