Effect of grass pollen immunotherapy on clinical and local immune response to nasal allergen challenge.

ABSTRACT:

Rationale

Nasal allergen provocations may be useful in investigating the pathophysiology of allergic rhinitis and effects of treatments.

Objective

To use grass pollen nasal allergen challenge (NAC) to investigate the effects of allergen immunotherapy in a cross-sectional study.

Methods

We studied nasal and cutaneous responses in untreated subjects with seasonal grass-pollen allergic rhinitis (n = 14) compared with immunotherapy-treated allergics (n = 14), plus a nonatopic control group (n = 14). Volunteers underwent a standardized NAC with 2000 biological units of timothy grass allergen (equivalent to 1.3 μg major allergen, Phl p5). Nasal fluid was collected and analysed by ImmunoCAP and multiplex assays. Clinical response was assessed by symptom scores and peak nasal

SUBMITTER: Scadding GW 

PROVIDER: S-EPMC4826905 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature