Aspirin in venous leg ulcer study (ASPiVLU): study protocol for a randomised controlled trial.

ABSTRACT:

Background

Venous leg ulceration is a common and costly problem that is expected to worsen as the population ages. Current treatment is compression therapy; however, up to 50 % of ulcers remain unhealed after 2 years, and ulcer recurrence is common. New treatments are needed to address those wounds that are more challenging to heal. Targeting the inflammatory processes present in venous ulcers is a possible strategy. Limited evidence suggests that a daily dose of aspirin may be an effective adjunct to aid ulcer healing and reduce recurrence. The Aspirin in Venous Leg Ulcer study (ASPiVLU) will investigate whether 300-mg oral doses of aspirin improve time to healing.

Methods/design

This randomised, double-blinded, multicentre, placebo-controlled, clinical trial will recruit p

SUBMITTER: Weller CD 

PROVIDER: S-EPMC4827178 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature