Long-term drug costs per life-month gained associated with first-line treatments for unresectable or metastatic melanoma.

ABSTRACT:

Background

For unresectable or metastatic melanoma, first-line ipilimumab has demonstrated long-term survival benefits over a 7-year period. First-line treatment with BRAF inhibitors has demonstrated efficacy in clinical trials with up to 3 years of follow-up. The long-term comparative efficacy and costs of ipilimumab and BRAF inhibitors are unknown.

Methods

Patient-level data from 12 clinical studies for ipilimumab were used. Survival data were extracted from included clinical trials for BRAF inhibitors based on a systematic literature review. Different parametric survival models, including exponential, Gompertz, log-normal, and Weibull models, were used to fit reported overall survival (OS) data and to project long-term survival for BRAF inhibitors. Survival benefits were

SUBMITTER: Liu JS 

PROVIDER: S-EPMC4827222 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature