Cell cycle features of C. elegans germline stem/progenitor cells vary temporally and spatially.

ABSTRACT: Many organisms accumulate a pool of germline stem cells during development that is maintained in later life. The dynamics of establishment, expansion and homeostatic maintenance of this pool are subject to both developmental and physiological influences including the availability of a suitable niche microenvironment, nutritional status, and age. Here, we investigated the dynamics of germline proliferation during stages of expansion and homeostasis, using the C. elegans germ line as a model. The vast majority of germ cells in the proliferative zone are in interphase stages of mitosis (G1, S, G2) rather than in the active mitotic (M) phase. We examined mitotic index and DNA content, comparing different life stages, mutants, and physiological conditions. We found that germ cells in larval sta

SUBMITTER: Roy D 

PROVIDER: S-EPMC4827254 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature