PD1-Expressing T Cell Subsets Modify the Rejection Risk in Renal Transplant Patients.

ABSTRACT: We tested whether multi-parameter immune phenotyping before or after renal -transplantation can predict the risk of rejection episodes. Blood samples collected before and weekly for 3 months after transplantation were analyzed by multi-parameter flow cytometry to define 52 T cell and 13 innate lymphocyte subsets in each sample, producing more than 11,000 data points that defined the immune status of the 28 patients included in this study. Principle component analysis suggested that the patients with histologically confirmed rejection episodes segregated from those without rejection. Protein death 1 (PD-1)-expressing subpopulations of regulatory and conventional T cells had the greatest influence on the principal component segregation. We constructed a statistical tool to predict rejection

SUBMITTER: Pike R 

PROVIDER: S-EPMC4827377 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature