Ontology highlight
ABSTRACT:
SUBMITTER: Al-Ahmadie HA
PROVIDER: S-EPMC4827439 | biostudies-literature | 2016 Apr
REPOSITORIES: biostudies-literature
Nature genetics 20160222 4
Plasmacytoid bladder cancer is an aggressive histologic variant with a high risk of disease-specific mortality. Using whole-exome and targeted sequencing, we find that truncating somatic alterations in the CDH1 gene occur in 84% of plasmacytoid carcinomas and are specific to this histologic variant. Consistent with the aggressive clinical behavior of plasmacytoid carcinomas, which frequently recur locally, CRISPR/Cas9-mediated knockout of CDH1 in bladder cancer cells enhanced cell migration. ...[more]