Association of vitamin D receptor gene variants with polycystic ovary syndrome: A case control study.

ABSTRACT:

Background

Vitamin D and insulin play an important role in susceptibility to polycystic ovary syndrome (PCOS), and therefore vitamin D receptor (VDR), parathyroid hormone (PTH), and insulin receptor (INSR) gene variants might be involved in the pathogenesis of PCOS.

Objective

The present study was designed to investigate the possible associations between polymorphisms in VDR, PTH, and INSR genes and the risk of PCOS.

Materials and methods

VDR, PTH, and INSR gene variants were genotyped in 35 women with PCOS and 35 controls using Polymerase chain reaction - Restriction fragment length polymorphism method. Furthermore, serum levels of glucose and insulin were measured in all participants.

Results

No significant differences were observed for the VDR FokI, VDR Tru9

SUBMITTER: Mahmoudi T 

PROVIDER: S-EPMC4827506 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature