The neural basis of drug stimulus processing and craving: an activation likelihood estimation meta-analysis.

ABSTRACT:

Background

The capacity of drug cues to elicit drug-seeking behavior is believed to play a fundamental role in drug dependence; yet the neurofunctional basis of human drug cue-reactivity is not fully understood. We performed a meta-analysis to identify brain regions that are consistently activated by presentation of drug cues. Studies involving treatment-seeking and nontreatment-seeking substance users were contrasted to determine whether there were consistent differences in the neural response to drug cues between these populations. Finally, to assess the neural basis of craving, consistency across studies in brain regions that show correlated activation with craving was assessed.

Methods

Appropriate studies, assessing the effect of drug-related cues or manipulations of dru

SUBMITTER: Chase HW 

PROVIDER: S-EPMC4827617 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature