Association of Serum Levels of Adipokines and Insulin With Risk of Barrett's Esophagus: A Systematic Review and Meta-Analysis.

ABSTRACT:

Background & aims

Metabolically active visceral fat may be associated with esophageal inflammation, metaplasia, and neoplasia. We performed a meta-analysis to evaluate the association of serum adipokines and insulin with Barrett's esophagus (BE).

Methods

We performed a systematic search of multiple electronic databases, through April 2015, to identify all studies reporting associations between leptin, adiponectin, insulin, insulin resistance, and risk of BE in adults. Comparing the highest study-specific category with the reference category for each hormone, we estimated the summary adjusted odds ratio (aOR) and 95% confidence intervals (CI), using a random effects model.

Results

We identified 9 observational studies (10 independent cohorts; 1432 patients with BE tota

SUBMITTER: Chandar AK 

PROVIDER: S-EPMC4827623 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature