Characterization of the Probiotic Yeast Saccharomyces boulardii in the Healthy Mucosal Immune System.

ABSTRACT: The probiotic yeast Saccharomyces boulardii has been shown to ameliorate disease severity in the context of many infectious and inflammatory conditions. However, use of S. boulardii as a prophylactic agent or therapeutic delivery vector would require delivery of S. boulardii to a healthy, uninflamed intestine. In contrast to inflamed mucosal tissue, the diverse microbiota, intact epithelial barrier, and fewer inflammatory immune cells within the healthy intestine may all limit the degree to which S. boulardii contacts and influences the host mucosal immune system. Understanding the nature of these interactions is crucial for application of S. boulardii as a prophylactic agent or therapeutic delivery vehicle. In this study, we explore both intrinsic and immunomodulatory properties of S. bou

SUBMITTER: Hudson LE 

PROVIDER: S-EPMC4827847 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature