Influence of Obesity and Metabolic Disease on Carotid Atherosclerosis in Patients with Coronary Artery Disease (CordioPrev Study).

ABSTRACT:

Background

Recent data suggest that the presence of associated metabolic abnormalities may be important modifiers of the association of obesity with a poorer prognosis in coronary heart disease. We determined the influence of isolated overweight and obesity on carotid intima media thickness (IMT-CC), and also assessed whether this influence was determined by the presence of metabolic abnormalities.

Methods

1002 participants from the CordioPrev study were studied at entry. We determined their metabolic phenotypes and performed carotid ultrasound assessment. We evaluated the influence of obesity, overweight and metabolic phenotypes on the IMT-CC.

Results

Metabolically sick participants (defined by the presence of two or more metabolic abnormalities) showed a greater IMT

SUBMITTER: Talavera-Garcia E 

PROVIDER: S-EPMC4827867 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature