Assessment of neonatal platelet adhesion, activation, and aggregation.

ABSTRACT:

Background

Acquired and inherited bleeding disorders may present in the neonatal period with devastating lifelong effects. Diagnosing bleeding disorders in the neonatal population could aid in preventing and treating the associated complications. However, currently available platelet function testing is limited in neonates, owing to difficulties in obtaining an adequate blood volume, a lack of normal reference ranges, and an incomplete understanding of the neonatal platelet functional phenotype.

Objective

To develop small-volume, whole blood platelet function assays in order to quantify and compare neonatal and adult platelet function.

Methods and results

Peripheral blood was obtained from healthy, full-term neonates at 24 h of life. Platelet activation, secretion and

SUBMITTER: Baker-Groberg SM 

PROVIDER: S-EPMC4828266 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature