Development of 3D Microvascular Networks Within Gelatin Hydrogels Using Thermoresponsive Sacrificial Microfibers.

ABSTRACT: A 3D microvascularized gelatin hydrogel is produced using thermoresponsive sacrificial poly(N-isopropylacrylamide) microfibers. The capillary-like microvascular network allows constant perfusion of media throughout the thick hydrogel, and significantly improves the viability of human neonatal dermal fibroblasts encapsulated within the gel at a high density.

SUBMITTER: Lee JB 

PROVIDER: S-EPMC4828275 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature