EQ-5D Utilities in Chronic Spontaneous/Idiopathic Urticaria.

ABSTRACT:

Objectives

To obtain utility estimates suitable for use in economic models for chronic spontaneous (idiopathic) urticaria (CSU).

Methods

Patient-level data from three randomized clinical trials-ASTERIA I, ASTERIA II and GLACIAL-were analysed. Health states were derived from the Urticaria Activity Score over 7 days (UAS7); higher scores denote greater activity. The health state score ranges were urticaria free: 0; well-controlled urticaria: 1-6; mild urticaria: 7-15; moderate urticaria: 16-27; and severe urticaria: 28-42. The mean EQ-5D utilities were calculated for each health state. A mixed model was used to predict the EQ-5D according to UAS7 health states in a pooled data set containing all treatment arms and time points from the three trials. Pooled trial data were valid

SUBMITTER: Hawe E 

PROVIDER: S-EPMC4828466 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature