Micron-scale plasma membrane curvature is recognized by the septin cytoskeleton.

ABSTRACT: Cells change shape in response to diverse environmental and developmental conditions, creating topologies with micron-scale features. Although individual proteins can sense nanometer-scale membrane curvature, it is unclear if a cell could also use nanometer-scale components to sense micron-scale contours, such as the cytokinetic furrow and base of neuronal branches. Septins are filament-forming proteins that serve as signaling platforms and are frequently associated with areas of the plasma membrane where there is micron-scale curvature, including the cytokinetic furrow and the base of cell protrusions. We report here that fungal and human septins are able to distinguish between different degrees of micron-scale curvature in cells. By preparing supported lipid bilayers on beads of differen

SUBMITTER: Bridges AA 

PROVIDER: S-EPMC4828694 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature