Association study of the PLXNA4 gene with the risk of Alzheimer's disease.

ABSTRACT:

Background

The Plexin-A 4 (PLXNA4) gene has recently been recognized as a functional candidate gene of late-onset Alzheimer's disease (LOAD). The single nucleotide polymorphism (SNP) rs13232207 of PLXNA4 gene has been reported to be associated with Alzheimer's disease (AD) in Japanese cohorts. We sought to clarify whether this novel locus gains the same effect in northern Han Chinese.

Methods

To investigate the relationship between SNP rs13232207 and AD sufferers, a case-control study of unrelated individuals was conducted with a total sample size of 2,318 subjects (978 cases and 1,340 age and gender matched healthy controls) in a Northern Han Chinese population. SPSS 22.0 was applied for the statistical process.

Results

No significant difference in polymorphic distri

SUBMITTER: Wang H 

PROVIDER: S-EPMC4828739 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature