The trans fatty acid elaidate affects the global DNA methylation profile of cultured cells and in vivo.

ABSTRACT:

Background

The deleterious effects of dietary trans fatty acids (tFAs) on human health are well documented. Although significantly reduced or banned in various countries, tFAs may trigger long-term responses that would represent a valid human health concern, particularly if tFAs alter the epigenome.

Methods

Based on these considerations, we asked whether the tFA elaidic acid (EA; tC18:1) has any effects on global DNA methylation and the transcriptome in cultured human THP-1 monocytes, and whether the progeny of EA-supplemented dams during either pregnancy or lactation in mice (n = 20 per group) show any epigenetic change after exposure.

Results

EA induced a biphasic effect on global DNA methylation in THP-1 cells, i.e. hypermethylation in the 1-50 μM concentration ran

SUBMITTER: Flores-Sierra J 

PROVIDER: S-EPMC4828757 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature