Global genetic diversity of the Plasmodium vivax transmission-blocking vaccine candidate Pvs48/45.

ABSTRACT:

Background

Plasmodium vivax 48/45 protein is expressed on the surface of gametocytes/gametes and plays a key role in gamete fusion during fertilization. This protein was recently expressed in Escherichia coli host as a recombinant product that was highly immunogenic in mice and monkeys and induced antibodies with high transmission-blocking activity, suggesting its potential as a P. vivax transmission-blocking vaccine candidate. To determine sequence polymorphism of natural parasite isolates and its potential influence on the protein structure, all pvs48/45 sequences reported in databases from around the world as well as those from low-transmission settings of Latin America were compared.

Methods

Plasmodium vivax parasite isolates from malaria-endemic regions of Colombia, Bra

SUBMITTER: Vallejo AF 

PROVIDER: S-EPMC4828788 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature