FMRI and MRS measures of neuroplasticity in the pharyngeal motor cortex.

ABSTRACT:

Introduction

Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS).

Methods

Healthy adults (n=11, 38±9years old) were randomised to receive real and sham PA

SUBMITTER: Michou E 

PROVIDER: S-EPMC4828970 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature