High Resolution Ultrasound and Photoacoustic Imaging of Orthotopic Lung Cancer in Mice: New Perspectives for Onco-Pharmacology.

ABSTRACT:

Objectives

We have developed a relevant preclinical model associated with a specific imaging protocol dedicated to onco-pharmacology studies in mice.

Materials and methods

We optimized both the animal model and an ultrasound imaging procedure to follow up longitudinally the lung tumor growth in mice. Moreover we proposed to measure by photoacoustic imaging the intratumoral hypoxia, which is a crucial parameter responsible for resistance to therapies. Finally, we compared ultrasound data to x-ray micro computed tomography and volumetric measurements to validate the relevance of this approach on the NCI-H460 human orthotopic lung tumor.

Results

This study demonstrates the ability of ultrasound imaging to detect and monitor the in vivo orthotopic lung tumor growth by hig

SUBMITTER: Raes F 

PROVIDER: S-EPMC4829195 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature