Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.

ABSTRACT:

Objective

The objective of the study was to study the genetic risk factors of spontaneous preterm birth (PTB) in African Americans.

Study design

Case-control analyses were performed using maternal and fetal deoxyribonucleic acid from 279 African American birth events (82 PTB and 197 term) and 1432 single-nucleotide polymorphisms from 130 candidate genes. Single-locus association and haplotype analyses were performed.

Results

The most significant associations were in the maternal interleukin (IL)-15 (rs10833, allele P = 2.91 x 10(-4), genotype P = 2.00 x 10(-3)) gene and the fetal IL-2 receptor B (IL-2RB) (rs84460, allele P = 1.37 x 10(-4), genotype P = 6.29 x 10(-4)) gene. The best models for these markers were additive (rs10833, odds ratio [OR], 0.30; 95% confidence

SUBMITTER: Velez DR 

PROVIDER: S-EPMC4829203 | biostudies-literature | 2009 Feb

REPOSITORIES: biostudies-literature