High Incidence of Tuberculosis in the Absence of Isoniazid and Cotrimoxazole Preventive Therapy in Children Living with HIV in Northern Ethiopia: A Retrospective Follow-Up Study.

ABSTRACT:

Objective

To identify the incidence of and predictors for tuberculosis in children living with HIV in Northern Ethiopia.

Design

Observational, retrospective follow-up study.

Methods

A total of 645 HIV-infected children were observed between September 2009 and September 2014. Cox regression analysis was used to identify predictors for developing TB.

Results

The incidence rate of tuberculosis was 4.2 per 100 child-years. Incidence of tuberculosis was higher for subjects who were not on cotrimoxazole preventive therapy, were not on isoniazid preventive therapy, had delayed motor development, had a CD4 cell count below the threshold, had hemoglobin level less than 10 mg/dl and were assessed as World Health Organization (WHO) clinical stage III or IV.

Conclusion<

SUBMITTER: Alemu YM 

PROVIDER: S-EPMC4829210 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature