Dimethyl fumarate selectively reduces memory T cells in multiple sclerosis patients.

ABSTRACT:

Background

Dimethyl fumarate (DMF) alters the phenotype of circulating immune cells and causes lymphopenia in a subpopulation of treated multiple sclerosis (MS) patients.

Objective

To phenotypically characterize circulating leukocytes in DMF-treated MS patients.

Methods

Cross-sectional observational comparisons of peripheral blood from DMF-treated MS patients (n = 17 lymphopenic and n = 24 non-lymphopenic), untreated MS patients (n = 17) and healthy controls (n = 23); immunophenotyped using flow cytometry. Longitudinal samples were analyzed for 13 DMF-treated patients.

Results

Lymphopenic DMF-treated patients had significantly fewer circulating CD8(+) and CD4(+) T cells, CD56(dim) natural killer (NK) cells, CD19(+) B cells and plasmacytoid dendritic cells when

SUBMITTER: Longbrake EE 

PROVIDER: S-EPMC4829494 | biostudies-literature | 2016 Jul

REPOSITORIES: biostudies-literature