The Pattern of Longitudinal Change in Serum Creatinine and 90-Day Mortality After Major Surgery.

ABSTRACT:

Objective

Calculate mortality risk that accounts for both severity and recovery of postoperative kidney dysfunction using the pattern of longitudinal change in creatinine.

Background

Although the importance of renal recovery after acute kidney injury (AKI) is increasingly recognized, the complex association that accounts for longitudinal creatinine changes and mortality is not fully described.

Methods

We used routinely collected clinical information for 46,299 adult patients undergoing major surgery to develop a multivariable probabilistic model optimized for nonlinearity of serum creatinine time series that calculates the risk function for 90-day mortality. We performed a 70/30 cross validation analysis to assess the accuracy of the model.

Results

All creatini

SUBMITTER: Korenkevych D 

PROVIDER: S-EPMC4829495 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature