A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration.

ABSTRACT: The traditional production methods of porous magnesium scaffolds are difficult to accurately control the pore morphologies and simultaneously obtain appropriate mechanical properties. In this work, two open-porous magnesium scaffolds with different pore size but in the nearly same porosity are successfully fabricated with high-purity Mg ingots through the titanium wire space holder (TWSH) method. The porosity and pore size can be easily, precisely and individually controlled, as well as the mechanical properties also can be regulated to be within the range of human cancellous bone by changing the orientation of pores without sacrifice the requisite porous structures. In vitro cell tests indicate that the scaffolds have good cytocompatibility and osteoblastic differentiation properties. In

SUBMITTER: Cheng MQ 

PROVIDER: S-EPMC4829853 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature