TNFα and IL-6 Responses to Particulate Matter in Vitro: Variation According to PM Size, Season, and Polycyclic Aromatic Hydrocarbon and Soil Content.

ABSTRACT:

Background

Observed seasonal differences in particulate matter (PM) associations with human health may be due to their composition and to toxicity-related seasonal interactions.

Objectives

We assessed seasonality in PM composition and in vitro PM pro-inflammatory potential using multiple PM samples.

Methods

We collected 90 weekly PM10 and PM2.5 samples during the rainy-warm and dry-cold seasons in five urban areas with different pollution sources. The elements, polycyclic aromatic hydrocarbons (PAHs), and endotoxins identified in the samples were subjected to principal component analysis (PCA). We tested the potential of the PM to induce tumor necrosis factor alpha (TNFα) and interleukin 6 (IL-6) secretion in cultured human monocytes (THP-1), and we modeled pro-inflam

SUBMITTER: Manzano-Leon N 

PROVIDER: S-EPMC4829995 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature