Transcriptomic analysis of the stationary phase response regulator SpdR in Caulobacter crescentus.

ABSTRACT:

Background

As bacterial cells enter stationary phase, they adjust their growth rate to comply with nutrient restriction and acquire increased resistance to several stresses. These events are regulated by controlling gene expression at this phase, changing the mode of exponential growth into that of growth arrest, and increasing the expression of proteins involved in stress resistance. The two-component system SpdR/SpdS is required for the activation of transcription of the Caulobacter crescentus cspD gene at the onset of stationary phase.

Results

In this work, we showed that both SpdR and SpdS are also induced upon entry into stationary phase, and this induction is partly mediated by ppGpp and it is not auto-regulated. Global transcriptional analysis at early stationary phas

SUBMITTER: da Silva CA 

PROVIDER: S-EPMC4830024 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature