Genetic and Environmental Contributions to Functional Connectivity Architecture of the Human Brain.

ABSTRACT: One of the grand challenges faced by neuroscience is to delineate the determinants of interindividual variation in the comprehensive structural and functional connection matrices that comprise the human connectome. At present, this endeavor appears most tractable at the macroanatomic scale, where intrinsic brain activity exhibits robust patterns of synchrony that recapitulate core functional circuits at the individual level. Here, we use a classical twin study design to examine the heritability of intrinsic functional network properties in 101 twin pairs, including network activity (i.e., variance of a network's specific temporal fluctuations) and internetwork coherence (i.e., correlation between networks' specific temporal fluctuations). Five of 7 networks exhibited significantly heritabl

SUBMITTER: Yang Z 

PROVIDER: S-EPMC4830303 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature