Clinical Efficacy of Stem Cell Therapy for Diabetes Mellitus: A Meta-Analysis.

ABSTRACT:

Background

Stem cell therapy is a promising therapeutic modality for advanced diabetes mellitus (DM). This study presents a meta-analysis of relevant clinical trials to determine the efficacy of stem cell therapy in DM. We aim to critically evaluate and synthesize clinical evidence on the safety and efficiency of different types of stem cell therapy for both T1DM and T2DM.

Methods and findings

We pooled participant-level data from twenty-two eligible clinical trials that satisfied our inclusion criteria, with a total of 524 patients. There were significant differences in the outcome based on the type and source of the infused cells. Out of all T1DM patients who received CD34+ hematopoietic stem cell (HSC) infusion, 58.9% became insulin independent for a mean period of 16 mon

SUBMITTER: El-Badawy A 

PROVIDER: S-EPMC4830527 | biostudies-literature | 2016

REPOSITORIES: biostudies-literature