Estimated Maximal Safe Dosages of Tumescent Lidocaine.

ABSTRACT:

Background

Tumescent lidocaine anesthesia consists of subcutaneous injection of relatively large volumes (up to 4 L or more) of dilute lidocaine (≤1 g/L) and epinephrine (≤1 mg/L). Although tumescent lidocaine anesthesia is used for an increasing variety of surgical procedures, the maximum safe dosage is unknown. Our primary aim in this study was to measure serum lidocaine concentrations after subcutaneous administration of tumescent lidocaine with and without liposuction. Our hypotheses were that even with large doses (i.e., >30 mg/kg), serum lidocaine concentrations would be below levels associated with mild toxicity and that the concentration-time profile would be lower after liposuction than without liposuction.

Methods

Volunteers participated in 1 to 2 infiltration stud

SUBMITTER: Klein JA 

PROVIDER: S-EPMC4830750 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature