Interindividual variation in gene expression responses and metabolite formation in acetaminophen-exposed primary human hepatocytes.

ABSTRACT: Acetaminophen (APAP) is a readily available over-the-counter drug and is one of the most commonly used analgesics/antipyretics worldwide. Large interindividual variation in susceptibility toward APAP-induced liver failure has been reported. However, the exact underlying factors causing this variability in susceptibility are still largely unknown. The aim of this study was to better understand this variability in response to APAP by evaluating interindividual differences in gene expression changes and APAP metabolite formation in primary human hepatocytes (PHH) from several donors (n = 5) exposed in vitro to a non-toxic to toxic APAP dose range. To evaluate interindividual variation, gene expression data/levels of metabolites were plotted against APAP dose/donor. The correlation in APAP dos

SUBMITTER: Jetten MJ 

PROVIDER: S-EPMC4830893 | biostudies-literature | 2016 May

REPOSITORIES: biostudies-literature